Cell Annotation
Platform

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scRNA-seq of human of the human retinal pigment epithelium and the choroid

Main

Cell Metadata

Ontology Term: retinal pigment epithelial cellCL:0002586
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: retinal cellCL:0009004
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: RPE65, BEST1, CDK2AP2
Canonical Marker Genes: RPE65, BEST1, CDK2AP2
Rationale: This RPE sub-class is annotated by the markers RPE65, BEST1, CDK2AP2

Set of Labels Description: This cell annotation dataset focuses on the human retinal pigment epithelium (RPE) and choroid, which are essential for the survival and proper function of the neural retina in the human eye. Using single-cell RNA-seq (scRNA-seq), we analyzed over 180K cells from 67 donors. This comprehensive dataset enabled the identification 15 major cell classes and 27 sub-classes. As part of the Human Cell Atlas initiative, this resource lays a robust foundation for advancing research into the biology of the RPE and choroid and the diseases associated with these tissues.
Annotation Method: manual