Human Gut Cell Atlas (HGCA) v1 - Epithelial Lineage

BEST4 Colonocytes

Ontology Term

BEST4+ colonocyteCL:4047052

Synonyms

Terms that have the same, or nearly the same, meaning as the selected cell type.

unknown

Category

Class of which the cell type is a subclass.

colonocyteCL:1000347

Ontology Assessment

Disagreements with any aspect of the Cell Ontology.

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Marker Gene Evidence

Gene markers used by researcher to assign this cell annotation.

BEST4, SPIB, OTOP2, CA7

Canonical Marker Genes

BEST4, OTOP2, SPIB

Rationale

BEST4 is found to differentiate a subcluster of colonocytes across multiple gut epithelial datasets, and is often the only marker needed to identify this subset

Inherited from hgca_celltype_v1

Set of Labels Description

Cell annotations based on two rounds of subclustering with scVI integration, sample_id as batch key. Cell annotations were refined by expert feedback based on "prelim annotation" on CAP. Prelim annotation is renamed "hgca_celltype_v0" here and the feedback on the "prelim annotation" is available by selecting a previous version of the Integrated Human Gut Atlas on CAP.

Annotation Method

both

Algorithm Name

scIB

Algorithm Version

1.2.1

Algorithm URL

https://github.com/theislab/scib