Mapping hormone-regulated cell-cell interaction networks in the human breast at single-cell resolution (Murrow et al. 2022)

Basal (B-Myo)

Ontology Term: basal-myoepithelial cell of mammary glandCL:0002324
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: basal, myoepithelial cell of mammary gland, basal cell of lactiferous duct, BM, basal myoepithelial cell, B-Myo cell, basal-myoepithelial cell, myoepithelial cell of lactiferous gland
Category Class of which the cell type is a subclass.: myoepithelial cellCL:0000185
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: ACTA2, ACTG2, KRT14, KRT17, KRT5, MYLK, SFN, TAGLN
Canonical Marker Genes: KRT14, KRT5, KRT17, ACTA2, ACTG2, TAGLN, MYL9, MYLK
Negative Marker Genes Genes expected to be absent, or expressed at a notably low level, in these cells, and whose absence supports the assignment of this cell annotation.: —
Rationale: This gene expression profile combines classical basal cytokeratins (KRT5, KRT14, KRT17) with the full smooth-muscle contractile machinery (ACTA2, ACTG2, TAGLN, MYL9, MYLK) and basal lineage regulator SFN. This profile definitively identifies the cluster as Basal/Myoepithelial Cells in the mammary gland. Unified nomenclature: basal-myoepithelial (B-Myo)

Set of Labels Description: Cell type annotation based on clustering and marker analysis.
Annotation Method: manual