Mapping hormone-regulated cell-cell interaction networks in the human breast at single-cell resolution (Murrow et al. 2022)

Secretory_Luminal (LASP)

Ontology Term: luminal adaptive secretory precursor cell of mammary glandCL:4033057
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: LASP, LP, alveolar progenitor, AP, LumSec, alveolar cell, luminal progenitor cell, ER-negative luminal alveolar progenitor, AV, luminal progenitor, luminal secretory cell
Category Class of which the cell type is a subclass.: luminal epithelial cell of mammary glandCL:0002326
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: ELF3, EPCAM, KRT18, KRT19, KRT8, ALDH1A3, BBOX1, GABRP, KIT, KRT15, LTF, PROM1, SLPI
Canonical Marker Genes: EPCAM, KRT8, KRT18, KRT19, ALDH1A3, SLPI, GABRP
Rationale: This gene expression signature combines key luminal cytoskeletal and adhesion markers (EPCAM, KRT8, KRT18, KRT19) with canonical progenitor and secretory effectors (KIT, ALDH1A3, SLPI, LTF, GABRP). This co-expression profile definitively classifies this cluster as Luminal Progenitor Cells/Secretory luminal cells within the mammary epithelium. Unified nomenclature: luminal adaptive secretory precursor (LASP)

Set of Labels Description: Cell type annotation based on clustering and marker analysis.
Annotation Method: manual