Mapping hormone-regulated cell-cell interaction networks in the human breast at single-cell resolution (Murrow et al. 2022)

Vascular_Accessory

Ontology Term: pericyteCL:0000669
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: pericyte of Rouget, adventitial reticular cell, pericyte cell, adventitial cell, cell of Rouget, ARC
Category Class of which the cell type is a subclass.: mural cellCL:0008034
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: CPM, ENPEP, GJA4, KCNE4, PLN, RGS5, TAGLN
Canonical Marker Genes: RGS5, ENPEP, CPM, PLN, KCNE4, GJA4
Negative Marker Genes Genes expected to be absent, or expressed at a notably low level, in these cells, and whose absence supports the assignment of this cell annotation.: —
Rationale: This cluster is defined by high expression of perivascular identity genes (RGS5, ENPEP, CPM), calcium/ion regulatory machinery (PLN, KCNE4), and heterocellular junction components (GJA4). This transcriptional signature confirms the identity of these cells as Pericytes / Perivascular Mural Cells.

Set of Labels Description: Cell type annotation based on clustering and marker analysis.
Annotation Method: manual