Single-nucleus transcriptomic profiling of human skeletal muscle from healthy adults

Vascular Endothelial Cell

Ontology Term

blood vessel endothelial cellCL:0000071

Synonyms

Terms that have the same, or nearly the same, meaning as the selected cell type.

unknown

Category

Class of which the cell type is a subclass.

endothelial cell of vascular treeCL:0002139

Ontology Assessment

Disagreements with any aspect of the Cell Ontology.

—

Marker Gene Evidence

Gene markers used by researcher to assign this cell annotation.

VWF, PECAM1, KDR, CDH5, SPARCL1, CD36, PTPRM

Canonical Marker Genes

ADGRF5, B2M, PTPRB, TIMP3, PECAM1, VWF

Rationale

Endothelial cells were defined by high expression of vascular markers VWF, CD36, SPARCL1, LDB2, PTPRM, TIMP3, and DOCK9, with VWF and SPARCL1 being among the most specific differentially expressed genes.

Inherited from author_cell_type

Set of Labels Description

Cell annotations were generated with scType using marker genes curated from related publications, and then manually reviewed and adjusted based on the top highly variable genes in each Leiden cluster.

Annotation Method

both

Algorithm Name

scType

Algorithm Version

v1

Algorithm URL

https://github.com/IanevskiAleksandr/sc-type

• v1 Tissue-wide single-cell multiomic analysis of human gene regulation and cell diversity
• Single-nucleus transcriptomic profiling of human skeletal muscle from healthy adults