Integrated Human Breast Cell Atlas v1.0 - all cells

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Cell Metadata

Luminal hormone sensing

Ontology Term: luminal hormone-sensing cell of mammary glandCL:4033058
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: LHS cell, luminal HR cell, hormone-responsive luminal cell, ER+ luminal cell, LumHR cell
Category Class of which the cell type is a subclass.: mammary gland epithelial cellCL:0002327
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: SCGB2A2, PIP, SCGB1D2, MUCL1, KRT8, SYTL2, TFF3
Canonical Marker Genes: ESR1, PGR, AR, FOXA1, GATA3, TFF1
Rationale: Luminal hormone sensing (LHS) cells were identified and annotated based on ESR1+/PGR+/FOXA1+/GATA3+ expression. These cells are the ER+ luminal compartment responsible for hormone signal reception in the breast epithelium. See Reed et al. 2024 (Nature Genetics) for characterization. Note: formerly labeled 'LumHR' — standardized to LHS in this atlas version.
Rationale DOI: 10.1038/s41588-024-01688-9 10.1038/s41586-023-06252-9

Set of Labels Description: Cell annotations based on resolution broad clustering using the Leiden algorithm.
Annotation Method: manual

Ontology Term: luminal hormone-sensing cell of mammary glandCL:4033058
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: LHS cell, luminal HR cell, hormone-responsive luminal cell, ER+ luminal cell, LumHR cell
Category Class of which the cell type is a subclass.: mammary gland epithelial cellCL:0002327
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: SCGB2A2, PIP, SCGB1D2, MUCL1, KRT8, SYTL2, TFF3
Canonical Marker Genes: ESR1, PGR, AR, FOXA1, GATA3, TFF1
Rationale: Luminal hormone sensing (LHS) cells were identified and annotated based on ESR1+/PGR+/FOXA1+/GATA3+ expression. These cells are the ER+ luminal compartment responsible for hormone signal reception in the breast epithelium. See Reed et al. 2024 (Nature Genetics) for characterization. Note: formerly labeled 'LumHR' — standardized to LHS in this atlas version.
Rationale DOI: 10.1038/s41588-024-01688-9 10.1038/s41586-023-06252-9

Set of Labels Description: Cell annotations based on resolution broad clustering using the Leiden algorithm.
Annotation Method: manual