Integrated Human Breast Cell Atlas v1.0 - all cells

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Cell Metadata

Perivascular

Ontology Term: perivascular cellCL:4033054
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: perivascular cell, mural cell, pericyte of breast
Category Class of which the cell type is a subclass.: stromal cellCL:0000499
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: COL6A3, SERPINE1, CXCL3, CTSC, CFD, CD36
Canonical Marker Genes: RGS5, PDGFRB, ACTA2, MYH11, CALD1
Rationale: Perivascular cells (pericytes) were identified and annotated based on RGS5+/PDGFRB+/ACTA2+ expression. These mural cells surround blood vessel endothelium and regulate vascular tone. The label 'Perivascular' was used by original contributing studies; CL:4033054 is the matched ontology term.
Rationale DOI: 10.1038/s41588-024-01688-9 10.1038/s41586-023-06252-9

Set of Labels Description: Cell annotations based on resolution broad clustering using the Leiden algorithm.
Annotation Method: manual

Ontology Term: perivascular cellCL:4033054
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: perivascular cell, mural cell, pericyte of breast
Category Class of which the cell type is a subclass.: stromal cellCL:0000499
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: COL6A3, SERPINE1, CXCL3, CTSC, CFD, CD36
Canonical Marker Genes: RGS5, PDGFRB, ACTA2, MYH11, CALD1
Rationale: Perivascular cells (pericytes) were identified and annotated based on RGS5+/PDGFRB+/ACTA2+ expression. These mural cells surround blood vessel endothelium and regulate vascular tone. The label 'Perivascular' was used by original contributing studies; CL:4033054 is the matched ontology term.
Rationale DOI: 10.1038/s41588-024-01688-9 10.1038/s41586-023-06252-9

Set of Labels Description: Cell annotations based on resolution broad clustering using the Leiden algorithm.
Annotation Method: manual