Human intercostal skeletal muscle aging atlas (scRNA-seq and snRNA-seq, young vs aged)

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Cell Metadata

FB

Ontology Term: skeletal muscle fibroblastCL:0011027
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: muscle fibroblast, stromal fibroblast, FB
Category Class of which the cell type is a subclass.: fibroblastCL:0000057
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: PDGFRA, DCN, FBN1, PRG4, PCOLCE2, CD70, COL4A1, COL15A1, ALDH1A2
Canonical Marker Genes: COL1A1, DCN, PDGFRA
Rationale: This cell was annotated manually using canonical markers in the field for fibroblasts (PDGFRA and DCN) and specific subsets including adventitial: FBN1, PRG4, PCOLCE2, CD70 and parenchymal fibroblasts:COL4A1, COL15A1, ALDH1A2. We noticed DCN, CFD, APOD running differential expression.
Rationale DOI: 10.1038/s41586-021-03549-5

Set of Labels Description: Displayed cell annotations represent 43 coarse cell type clusters derived using combined manual and automatic annotation using CellTypist.
Annotation Method: both
Algorithm Name: CellTypist
Algorithm Version: v1.7
Algorithm URL: https://github.com/Teichlab/celltypist

Ontology Term: skeletal muscle fibroblastCL:0011027
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: muscle fibroblast, stromal fibroblast, FB
Category Class of which the cell type is a subclass.: fibroblastCL:0000057
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: PDGFRA, DCN, FBN1, PRG4, PCOLCE2, CD70, COL4A1, COL15A1, ALDH1A2
Canonical Marker Genes: COL1A1, DCN, PDGFRA
Rationale: This cell was annotated manually using canonical markers in the field for fibroblasts (PDGFRA and DCN) and specific subsets including adventitial: FBN1, PRG4, PCOLCE2, CD70 and parenchymal fibroblasts:COL4A1, COL15A1, ALDH1A2. We noticed DCN, CFD, APOD running differential expression.
Rationale DOI: 10.1038/s41586-021-03549-5

Set of Labels Description: Displayed cell annotations represent 43 coarse cell type clusters derived using combined manual and automatic annotation using CellTypist.
Annotation Method: both
Algorithm Name: CellTypist
Algorithm Version: v1.7
Algorithm URL: https://github.com/Teichlab/celltypist