Human intercostal skeletal muscle aging atlas (scRNA-seq and snRNA-seq, young vs aged)

CD4+T

Ontology Term

CD4-positive, alpha-beta T cellCL:0000624

Synonyms

Terms that have the same, or nearly the same, meaning as the selected cell type.

CD4 T cell, T helper, CD4+ alpha-beta T lymphocyte

Category

Class of which the cell type is a subclass.

alpha-beta T cellCL:0000789

Ontology Assessment

Disagreements with any aspect of the Cell Ontology.

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Marker Gene Evidence

Gene markers used by researcher to assign this cell annotation.

CD3D, IL7R, SELL, CCR7

Canonical Marker Genes

CD4, CD3D, IL7R

Rationale

This cell was annotated with CellTypist using the Immune_All_Low model trained on the cross-tissue immune cell atlas (DOI: 10.1126/science.abl5197). Canonical markers in the field include CD3D, IL7R, SELL, CCR7; we noticed IL7R, CD3D, CD3G running differential expression. Helper / regulatory T cell.

Rationale DOI

10.1126/science.abl5197

Inherited from author_cell_type

Set of Labels Description

Displayed cell annotations represent 43 coarse cell type clusters derived using combined manual and automatic annotation using CellTypist.

Annotation Method

both

Algorithm Name

CellTypist

Algorithm Version

v1.7

Algorithm URL

https://github.com/Teichlab/celltypist