Human intercostal skeletal muscle aging atlas (scRNA-seq and snRNA-seq, young vs aged)

CD16+NK

Ontology Term

CD16-positive, CD56-dim natural killer cell, humanCL:0000939

Synonyms

Terms that have the same, or nearly the same, meaning as the selected cell type.

CD56dim NK cell, cytotoxic NK

Category

Class of which the cell type is a subclass.

natural killer cellCL:0000623

Ontology Assessment

Disagreements with any aspect of the Cell Ontology.

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Marker Gene Evidence

Gene markers used by researcher to assign this cell annotation.

FCGR3A, GZMB, FGFBP2, GNLY, PRF1, NKG7

Canonical Marker Genes

FCGR3A, GZMB, PRF1

Rationale

This cell was annotated with CellTypist using the Immune_All_Low model trained on the cross-tissue immune cell atlas (DOI: 10.1126/science.abl5197). Canonical markers in the field include FCGR3A, GZMB, FGFBP2, GNLY, PRF1, NKG7; we noticed GNLY, NKG7, KLRF1 running differential expression. Cytotoxic NK (CD56-dim).

Rationale DOI

10.1126/science.abl5197

Inherited from author_cell_type

Set of Labels Description

Displayed cell annotations represent 43 coarse cell type clusters derived using combined manual and automatic annotation using CellTypist.

Annotation Method

both

Algorithm Name

CellTypist

Algorithm Version

v1.7

Algorithm URL

https://github.com/Teichlab/celltypist