Abdominal subcutaneous adipose tissue (Loft et al., 2026, Nature Met)

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Cell Metadata

Lymphoid immune cells

Ontology Term: lymphocyteCL:0000542
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: leukocyteCL:0000738
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: IL7R, CD3E
Canonical Marker Genes: IL7R, CD3E
Rationale: IL7R (CD127) is expressed by T cells and other lymphoid populations and is critical for lymphocyte survival and homeostasis. CD3E is a core component of the T cell receptor complex and is selectively expressed in T lymphocytes. IL7R and CD3E identify lymphoid immune cell populations and distinguish them from myeloid and non-immune cells.
Rationale DOI: 10.1038/s42255-025-01296-9

Set of Labels Description: Annotation of all broad canonical cell populations present in AT were based on previously described markers from Loft et al. 2026 (PMID: 40360756).
Annotation Method: manual

Ontology Term: lymphocyteCL:0000542
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: leukocyteCL:0000738
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: IL7R, CD3E
Canonical Marker Genes: IL7R, CD3E
Rationale: IL7R (CD127) is expressed by T cells and other lymphoid populations and is critical for lymphocyte survival and homeostasis. CD3E is a core component of the T cell receptor complex and is selectively expressed in T lymphocytes. IL7R and CD3E identify lymphoid immune cell populations and distinguish them from myeloid and non-immune cells.
Rationale DOI: 10.1038/s42255-025-01296-9

Set of Labels Description: Annotation of all broad canonical cell populations present in AT were based on previously described markers from Loft et al. 2026 (PMID: 40360756).
Annotation Method: manual