Human Adipose Tissue Atlas v1.0 — Abdominal Subcutaneous WAT

LAMs

Ontology Term

lipid-associated macrophageCL:4033086

Synonyms

Terms that have the same, or nearly the same, meaning as the selected cell type.

LAM

Category

Class of which the cell type is a subclass.

macrophageCL:0000235

Ontology Assessment

Disagreements with any aspect of the Cell Ontology.

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Marker Gene Evidence

Gene markers used by researcher to assign this cell annotation.

MRC1, F13A1, CD9, TREM2, LPL

Canonical Marker Genes

MRC1, F13A1, CD9, TREM2, LPL

Rationale

MRC1 (CD206) and F13A1 are general macrophage markers broadly expressed across tissue-resident macrophage populations. CD9, TREM2, and LPL (lipoprotein lipase) show enriched expression in lipid-associated macrophages specifically, with TREM2 being a receptor involved in lipid sensing and metabolism. Together these markers identify lipid-associated macrophages (LAMs) and distinguish them from other macrophage subpopulations.

Rationale DOI

10.1038/s42255-025-01296-9

Inherited from lvl3_cell_types

Set of Labels Description

Level 3 cell type labels (most fine-grained).

Annotation Method

manual