Human Adipose Tissue Atlas v1.0 — Abdominal Subcutaneous WAT

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Cell Metadata

T & NK cells

Ontology Term: lymphocyteCL:0000542
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: lymphocyteCL:0000542
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: CD3D, CD3E, NCR1, NCAM1
Canonical Marker Genes: CD3D, CD3E, NCR1, NCAM1
Rationale: CD3D and CD3E are components of the T cell receptor signaling complex, confirming T cell lineage identity across all T cell subpopulations. NCR1 (NKp46) and NCAM1 (CD56) confirm NK cell lineage identity. Together these markers define the T and NK cell compartment encompassing CD4⁺, CD8⁺, regulatory, MAIT, proliferating T cells, ILC3s, and CD56⁺CD16⁺ and CD56⁺CD16⁻ NK cell subtypes.
Rationale DOI: 10.1038/s42255-025-01296-9 10.57785/e9e1-wh09

Set of Labels Description: Level 2 cell type labels (represents broad clusters most studies tend to identify).
Annotation Method: manual

Ontology Term: lymphocyteCL:0000542
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: lymphocyteCL:0000542
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: CD3D, CD3E, NCR1, NCAM1
Canonical Marker Genes: CD3D, CD3E, NCR1, NCAM1
Rationale: CD3D and CD3E are components of the T cell receptor signaling complex, confirming T cell lineage identity across all T cell subpopulations. NCR1 (NKp46) and NCAM1 (CD56) confirm NK cell lineage identity. Together these markers define the T and NK cell compartment encompassing CD4⁺, CD8⁺, regulatory, MAIT, proliferating T cells, ILC3s, and CD56⁺CD16⁺ and CD56⁺CD16⁻ NK cell subtypes.
Rationale DOI: 10.1038/s42255-025-01296-9 10.57785/e9e1-wh09

Set of Labels Description: Level 2 cell type labels (represents broad clusters most studies tend to identify).
Annotation Method: manual