Human Adipose Tissue Atlas v1.0 — Lymphoid cells

CD56⁺CD16⁻ Immature NK cells

Ontology Term

immature NK T cellCL:0000914

Synonyms

Terms that have the same, or nearly the same, meaning as the selected cell type.

mature natural killer T-lymphocyte, mature NK T lymphocyte, mature NKT cell, mature NK T-cell

Category

Class of which the cell type is a subclass.

natural killer cellCL:0000623

Ontology Assessment

Disagreements with any aspect of the Cell Ontology.

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Marker Gene Evidence

Gene markers used by researcher to assign this cell annotation.

NCR1, NCAM1, IL7R, SELL

Canonical Marker Genes

NCR1, NCAM1, IL7R, SELL

Rationale

NCR1 (NKp46) and NCAM1 (CD56) confirm NK cell lineage identity. IL7R (CD127) and SELL (CD62L) show enriched expression in immature and less differentiated NK cells, with SELL being associated with lymph node homing and an immature NK cell state. Together these markers identify immature NK cells and distinguish them from mature CD56⁺CD16⁺ and CD56⁺CD16⁻ NK cell populations.

Rationale DOI

10.57785/e9e1-wh0910.1038/s42255-025-01296-9

Inherited from lvl3_cell_types

Set of Labels Description

Level 3 cell type labels (most fine-grained).

Annotation Method

manual