Human Adipose Tissue Atlas v1.0 — Myeloid cells

cDC1

Ontology Term

conventional dendritic cellCL:0000990

Synonyms

Terms that have the same, or nearly the same, meaning as the selected cell type.

cDC, DC1, interdigitating cell, dendritic reticular cell, type 1 DC, veiled cell

Category

Class of which the cell type is a subclass.

dendritic cellCL:0000451

Ontology Assessment

Disagreements with any aspect of the Cell Ontology.

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Marker Gene Evidence

Gene markers used by researcher to assign this cell annotation.

FLT3, XCR1, CLEC9A, CADM1, DPP4

Canonical Marker Genes

FLT3, XCR1, CLEC9A, CADM1, DPP4

Rationale

FLT3 is a general dendritic cell marker expressed across DC progenitors and mature DC subsets. XCR1, CLEC9A (DNGR-1), CADM1, and DPP4 show enriched expression in cDC1s specifically, with XCR1 and CLEC9A being well-characterized surface markers of this subset involved in cross-presentation of antigens. Together these markers identify cDC1s and distinguish them from cDC2 and other dendritic cell subsets.

Rationale DOI

10.1038/s42255-025-01296-9

Inherited from lvl3_cell_types

Set of Labels Description

Level 3 cell type labels (most fine-grained).

Annotation Method

manual