Human semi-tendinosus and gracilis with and without acute exercise nuclei atlas - hamstring tendon nuclei

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Cell Metadata

MTJ

Ontology Term: myotendinous junction nucleusCL:4052024
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: extrafusal muscle fiberCL:0008046
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: COL22A1, TTN, ACTA1, NCAM1
Canonical Marker Genes: COL22A1, TNN
Rationale: MTJ myonuclei expressed COL22A1 together with TTN, ACTA1 and NCAM1, consistent with myotendinous junction-associated myonuclei.

Set of Labels Description: Cell annotations based on integrated clustering of human tendon single-nucleus RNA-sequencing data using Seurat. Clusters were annotated using canonical marker gene expression and comparison with published single-cell datasets, with refinement of selected populations by subclustering to identify distinct tendon cell states.
Annotation Method: manual

Ontology Term: myotendinous junction nucleusCL:4052024
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: unknown
Category Class of which the cell type is a subclass.: extrafusal muscle fiberCL:0008046
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: COL22A1, TTN, ACTA1, NCAM1
Canonical Marker Genes: COL22A1, TNN
Rationale: MTJ myonuclei expressed COL22A1 together with TTN, ACTA1 and NCAM1, consistent with myotendinous junction-associated myonuclei.

Set of Labels Description: Cell annotations based on integrated clustering of human tendon single-nucleus RNA-sequencing data using Seurat. Clusters were annotated using canonical marker gene expression and comparison with published single-cell datasets, with refinement of selected populations by subclustering to identify distinct tendon cell states.
Annotation Method: manual