Integrated Human Breast Cell Atlas v1.0 - all cells

Luminal adaptive secretory precursor

Ontology Term: luminal adaptive secretory precursor cellCL:4033057
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: LASP cell, luminal progenitor, adaptive luminal cell
Category Class of which the cell type is a subclass.: mammary gland epithelial cellCL:0002327
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: SCGB3A1, MMP7, TM4SF1, PTN, WFDC2, HMGB2, TOP2A
Canonical Marker Genes: KRT18, KRT8, SLPI, ANKRD36C, KRT7, ALDH1A3
Negative Marker Genes Genes expected to be absent, or expressed at a notably low level, in these cells, and whose absence supports the assignment of this cell annotation.: —
Rationale: Luminal adaptive secretory precursor (LASP) cells were identified and annotated by Austin Reed based on KRT18+/KRT8+/SLPI+/ALDH1A3+ expression. These cells represent a progenitor-like luminal population. See Reed et al. 2024 (Nature Genetics) for characterization.
Rationale DOI: 10.1038/s41588-024-01688-9 10.1038/s41586-023-06252-9

Set of Labels Description: Cell annotations based on resolution broad clustering using the Leiden algorithm.
Annotation Method: manual