The immune cells cluster too closely to the rest of the epithelial cells, and they are between tuft cells and enteroendocrine cells. They should cluster away from them.
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The immune cells cluster too closely to the rest of the epithelial cells, and they are between tuft cells and enteroendocrine cells. They should cluster away from them.
Stem cells are abundant and well labelled. Trans-amplifying cells (TA) are missing. These cells are the rapidly proliferating progeny of intestinal stem cells and represent an intermediate compartment between stem cells and fully differentiated epithelial lineages. They should express specific markers to distinguish them from stem cells and more differentiated cells.
I selected this option to provide general feedback. Separating small and large intestine would make the resource more informative and user-friendly for researchers focused on a specific intestinal segment, as cells from these regions can exhibit distinct marker profiles. Distinct clustering of small versus large intestine cells would also help clarify which cell populations are characteristic of each intestinal tract.
I am not sure about the markers chosen for these cells. Can we check if they express BEST4, OTOP2, CA7, GUCA2A/B, and SPIB? also APOA1, APOA4, which are apolipoproteins?
Agree on annotation, but not sure if they should cluster close to enteroendocrine cells
I agree with this cluster and cell type annotation
I agree on the annotation but I am not sure if it is correct that they cluster so close to the rest of the intestinal cell tpyes
The endothelial cells look to cluster very close to the epithelial cells and less close to the stromal cells. Can we check the markers?