merge with CD14_HIST1H1E
8.64k CD14_HIST1H1E and it is difficult to find a clear transcriptomic identity from 646.6k CD14_mono - would consider merging
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8.64k CD14_HIST1H1E and it is difficult to find a clear transcriptomic identity from 646.6k CD14_mono - would consider merging
they could be a dendric cells but it has low FCER1A o CD1c expression.
Almost none of the evidence markers are specific to the cluster as judged by DEGs. Give this non-specific markers besides general lineage markers (CD14) be dropped or updated?
e.g.-
- HLA-DQA2 expression_driven (t-rank ~3323 lineage) / supported (t-rank ~1717 overall). In the gene is not on the CiteSEQ/CytOF
This is also backed up by displaying evidence genes on the heatmap.
Somewhat specific:
- HLA-DQA1 specific (t-rank 85 lineage / 118 overall; coefficient ~78)
- HLA-DRA specific, in DE top (t-rank 14 lineage / 22 overall; very high coefficient ~774) surface HLA-DR; assayed by Ahern2022 (CITE-seq), SchulteSchrepping2020 (CyTOF) and Glass2020 (CyTOF)
See report at https://github.com/Cellular-Semantics/Atlas-reporter_HCAi/blob/hcai-protein-evidence-prompts/projects/HCAi/reports/CD14_HLA_DQA1.md
Low expression of C1Q to be a macrophage
8.64k CD14_HIST1H1E and it is difficult to find a clear transcriptomic identity from 646.6k CD14_mono - would consider merging