Single-nucleus RNA-seq of Asian Skeletal Muscle Reveals Ancestry-specific Regulatory Programs Across Metabolic States

fibroblast

Ontology Term

skeletal muscle fibroblastCL:0011027

Synonyms

Terms that have the same, or nearly the same, meaning as the selected cell type.

fibro-adipogenic progenitor, FAP, mesenchymal stromal cell

Category

Class of which the cell type is a subclass.

fibroblastCL:0000057

Ontology Assessment

Disagreements with any aspect of the Cell Ontology.

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Marker Gene Evidence

Gene markers used by researcher to assign this cell annotation.

SMOC2, COL3A1, COL1A1, PDGFRA, FBN1, PRG4, PCOLCE2, APOD, LUM, DCN

Canonical Marker Genes

SMOC2, COL3A1, COL1A1, PDGFRA, FBN1, PRG4, PCOLCE2, APOD, LUM, DCN

Rationale

Annotated based on canonical fibroblast/FAP markers. Mainly includes PRG4+ FAPs (FBN1, PRG4, PCOLCE2, APOD, LUM, DCN).

Inherited from author_cell_type

Set of Labels Description

Cell annotations are based on a Level 1 annotation scheme, assigning the most appropriate broad cell type label to each of the 11 clusters identified during integration.

Annotation Method

manual

• v1 Singapore Adult Metabolism Study (SAMS1&2)
• Single-nucleus RNA-seq of Asian Skeletal Muscle Reveals Ancestry-specific Regulatory Programs Across Metabolic States