This dataset consists of skeletal muscle snRNA-seq data from two cohorts: SAMS1 (cross-sectional) and SAMS2 (longitudinal weight-loss study). It includes samples from three Asian ancestries (Chinese, Malay, and Indian), comprising 8 lean, 4 obese individuals, and 6 samples from the longitudinal cohort (3 pre- and 3 post-weight loss, non-paired).