Single-nucleus RNA-seq of Asian Skeletal Muscle Reveals Ancestry-specific Regulatory Programs Across Metabolic States

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Cell Metadata

muscle fiber type 1

Ontology Term: slow muscle cellCL:0000189
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: type I muscle fiber, slow-twitch fiber, type 1 myonuclei
Category Class of which the cell type is a subclass.: cell of skeletal muscleCL:0000188
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: MYH7, MYL3, TPM3, TNNI1, TNNC1, ATP2A2, LDHB
Canonical Marker Genes: MYH7, MYL3, TPM3, TNNI1, TNNC1, ATP2A2, LDHB
Rationale: Annotated based on canonical slow/type I myofiber markers from snRNA-seq differential expression analysis. High expression of MYH7 (slow myosin heavy chain), MYL3, TPM3, TNNI1, TNNC1, ATP2A2.

Set of Labels Description: Cell annotations are based on a Level 1 annotation scheme, assigning the most appropriate broad cell type label to each of the 11 clusters identified during integration.
Annotation Method: manual

Ontology Term: slow muscle cellCL:0000189
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: type I muscle fiber, slow-twitch fiber, type 1 myonuclei
Category Class of which the cell type is a subclass.: cell of skeletal muscleCL:0000188
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: MYH7, MYL3, TPM3, TNNI1, TNNC1, ATP2A2, LDHB
Canonical Marker Genes: MYH7, MYL3, TPM3, TNNI1, TNNC1, ATP2A2, LDHB
Rationale: Annotated based on canonical slow/type I myofiber markers from snRNA-seq differential expression analysis. High expression of MYH7 (slow myosin heavy chain), MYL3, TPM3, TNNI1, TNNC1, ATP2A2.

Set of Labels Description: Cell annotations are based on a Level 1 annotation scheme, assigning the most appropriate broad cell type label to each of the 11 clusters identified during integration.
Annotation Method: manual